胃粘液素抗體Mucin 5AC相關標記     Alexa Fluor 350   Alexa Fluor 488   Alexa Fluor 555   Alexa Fluor 647   AP   APC   Biotin  Cy3   Cy5  
 Cy5.5   Cy7   FITC   Gold   HRP   PE   PE-Cy3   PE-CY5   PE-CY5.5   PE-CY7   RBITC  
英文名稱    Mucin 5AC
中文名稱    胃粘液素抗體
別    名    MUC5AC; Mucin-5AC; MUC5AC Glycoprotein; Mucin 5AC oligomeric mucus/gel forming; Apomucin; Gastric mucin; Major Airway Glycoprotein; MUC 5; MUC5; MUC5AC; Mucin 5 subtype AC tracheobronchial; Mucin 5 Subtypes A And C; Mucin 5 subtypes A and C tracheobronchial/gastric; Mucin 5AC oligomeric mucus/gel forming; TBM; Tracheobronchial mucin; MUC5A_HUMAN.
研究領域    腫瘤  細胞生物  免疫學  轉錄調節(jié)因子  
抗體來源    Rabbit
克隆類型    Polyclonal
交叉反應    Human, 
產品應用    ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量    683kDa
胃粘液素抗體Mucin 5AC細胞定位    細胞漿 細胞膜 細胞外基質 分泌型蛋白 
性    狀    Lyophilized or Liquid
濃    度    1mg/1ml
免 疫 原    KLH conjugated synthetic peptide derived from human Mucin 5AC, oligomeric mucus/gel-forming
亞    型    IgG
純化方法    affinity purified by Protein A
儲 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存條件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹    background:
Mucin is a high M.W. (>1,000 kDa) glycoprotein, expressed by mucus cells of the gastric epithelium and by goblet cells of the fetal, precancerous and cancerous colon, but not by those of the normal colon. It also appears in other epithelial tissues, which are embryologically derived from the foregut (epigastric and bronchial epithelium) and in Müller ducts (mucus cells of the endocervix and urethral epithelium near the prostatic utriculus). The expression of MUC5AC has been frequently observed in gastric carcinomas and may be used as a marker of gastric differentiation.

Function:
Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by the mucocilary system.

Subunit:
Multimeric. Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD).

Subcellular Location:
Secreted.

Tissue Specificity:
Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia. Overexpressed in a number of carcinomas. Also expressed in Barrett's esophagus epithelium and in the proximal duodenum.

Post-translational modifications:
C-, O- and N-glycosylated. O-glycosylated on the Thr-/Ser-rich tandem repeats. C-mannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during biosynthesis. 
Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a reactive group which could link the protein to a primary amide.

Similarity:
Contains 1 CTCK (C-terminal cystine knot-like) domain. 
Contains 2 VWFC domains. 
Contains 4 VWFD domains. 

Gene ID:
4586

Database links:
Entrez Gene: 4586 Human
Entrez Gene: 17833 Mouse
Entrez Gene: 682837 Rat
Omim: 158373 Human
SwissProt: P98088 Human
Unigene: 534332 Human
Unigene: 10789 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產品圖片